Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature‐induced periodontitis

Background and objective Periodontitis in diabetic patients is characterized by enhanced inflammation and aggravated tissue damage in comparison with that in non‐diabetic counterparts. The progression of periodontal damage under diabetic condition can be partly ascribed to hyperglycemia‐induced disturbance between immune activation and inflammation resolution, where macrophages are capable of participating given their plasticity in response to...