Original paper

AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines

Volume: 12, Issue: 1
Published: Jun 23, 2021
Abstract
Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility. Here we isolate an engineered variant, "AsCas12a Ultra", that increased editing efficiency to nearly 100% at all sites examined in HSPCs, iPSCs, T cells, and NK cells. We show that AsCas12a Ultra maintains high on-target specificity thereby mitigating the risk for off-target editing and...
Paper Details
Title
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines
Published Date
Jun 23, 2021
Volume
12
Issue
1
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