Effect of Clonally Expanded PD‐1highCXCR5 –CD4 + Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis
Abstract
Antinuclear antibody (ANA)-positive juvenile idiopathic arthritis (JIA) is characterized by synovial B cell hyperactivity, but the precise role of CD4+ T cells in promoting local B cell activation is unknown. This study was undertaken to determine the phenotype and function of synovial CD4+ T cells that promote aberrant B cell activation in JIA.Flow cytometry was performed to compare the phenotype and cytokine patterns of PD-1high CD4+ T cells...
Paper Details
Title
Effect of Clonally Expanded PD‐1highCXCR5 –CD4 + Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis
Published Date
Dec 15, 2021
Journal
Volume
74
Issue
1
Pages
150 - 162
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