Interleukin-6 and intrapulmonary shunt

We read with interest the article by Kotwica et al. [1] showing the utility of clinical pulse oximetry measurements to quantify shunt and ventilation–perfusion mismatch and their predictive value in severe coronavirus disease 2019 (COVID-19). The authors found that shunt correlated with markers of activated inflammatory response ( i.e. C-reactive protein) but not those of activated coagulation (such as D-dimer). Their results reinforce the...