Review paper
NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease
Abstract
NOTCH intercellular signaling mediates the communications between adjacent cells involved in multiple biological processes essential for tissue morphogenesis and homeostasis. The NOTCH1 mutations are the first identified human genetic variants that cause congenital bicuspid aortic valve (BAV) and calcific aortic valve disease (CAVD). Genetic variants affecting other genes in the NOTCH signaling pathway may also contribute to the development of...
Paper Details
Title
NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease
Published Date
Jun 22, 2021
Volume
8
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