W436, a novel SMART derivative, exhibits anti‐hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy

Hepatocellular carcinoma (HCC) is considered one of the most common primary liver cancers and the second leading cause of cancer‐associated mortality around the world annually. Therefore, it is urgent to develop novel drugs for HCC therapy. We synthesized a novel 4‐substituted‐methoxybenzoyl‐aryl‐thiazole (SMART) analog, (5‐(4‐aminopiperidin‐1‐yl)‐2‐phenyl‐2 H ‐1,2,3‐triazol‐4‐yl) (3,4,5‐trimethoxyphenyl) methanone (W436), with higher...