Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case–control study

Dehydroepiandrosterone (DHEA) has a protective role against several types of cancer, although its mechanisms of action are still unknown, it may be related to the antioxidant effect of DHEA. We hypothesized that DHEA has a preventive effect on the formation of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) DNA adduct in pancreatic cancer patients.Serum DHEAs were quantified by the ELISA method in 50 pancreatic cancer patients with histopathological...