Synthesis, aggregation and drug solubilization of block polyethers: Influence of branch number and central aromatic group

Three branched PEO-PPO polyethers TEPA, PEI and PAR with identical PEO and PPO blocks but varying branch numbers were synthesized. Commercially available tetrabranched Tetronic T904 was chosen for contrast. The influence of branch number and central aromatic group on self-assembly behaviors of four polyethers were investigated. The solubilization of hydrophobic drug olmesartan medoxomil and in vitro drug release behavior were evaluated for...