Trans-Ethnic Mendelian Randomization Study Reveals Causal Relationships Between Cardiometabolic Factors and Chronic Kidney Disease

Background: The chronic kidney disease (CKD) public health burden has not declined as expected with current interventions on treatments focusing only on the disease. This study aims to systematically estimate the causal roles of cardiometabolic risk factors on CKD in Europeans and East Asians using Mendelian randomization (MR). Methods: A total of 45 risk factors with genetic data in Europeans and 17 risk factors in East Asians were...