Polysaccharide supramolecular hydrogel microparticles based on carboxymethyl β-cyclodextrin/chitosan complex and EDTA-chitosan for controlled release of protein drugs

New pH-sensitive polysaccharide supramolecular hydrogel microparticles (HMPs) were constructed based on carboxymethyl β-cyclodextrin/chitosan inclusion complex (CM-β-CD/CS) and EDTA-chitosan (EDCS) in aqueous solution. The incorporation of components in HMPs was characterized by ultraviolet, fluorescence and FTIR spectroscopy. The morphology measurements of HMPs were investigated by particle size analyzer and fluorescence microscope. These...