PD‐1‐induced proliferating T cells exhibit a distinct transcriptional signature

Summary Ligation of the inhibitory receptor PD‐1 on T cells results in the inhibition of numerous cellular functions. Despite the overtly inhibitory outcome of PD‐1 signalling, there are additionally a collection of functions that are activated. We have observed that CD4 + T cells stimulated through the T‐cell receptor and PD‐1 primarily do not proliferate; however, there is a population of cells that proliferates more than T‐cell receptor...