Original paper
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration
Abstract
Intestinal organoids capture essential features of the intestinal epithelium such as crypt folding, cellular compartmentalization and collective movements. Each of these processes and their coordination require patterned forces that are at present unknown. Here we map three-dimensional cellular forces in mouse intestinal organoids grown on soft hydrogels. We show that these organoids exhibit a non-monotonic stress distribution that defines...
Paper Details
Title
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration
Published Date
Jun 21, 2021
Journal
Volume
23
Issue
7
Pages
745 - 757
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Notes
History