Integrated 'Omics in IPF: Where Do We Go From Here?

Published on Jun 28, 2021in American Journal of Respiratory Cell and Molecular Biology5.373
· DOI :10.1165/RCMB.2021-0238ED
Peter J. Castaldi30
Estimated H-index: 30
(Brigham and Women's Hospital)
#1Richard J. Allen (University of Leicester)H-Index: 9
#2Beatriz Guillen-Guio (ULL: University of La Laguna)H-Index: 5
Last. Louise V. Wain (NIHR: National Institute for Health Research)H-Index: 46
view all 66 authors...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Geno...
65 CitationsSource
Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual ...
407 CitationsSource
#1Yan Xu (Cincinnati Children's Hospital Medical Center)H-Index: 43
#2Takako Mizuno (Cedars-Sinai Medical Center)H-Index: 8
Last. Jeffrey A. WhitsettH-Index: 93
view all 12 authors...
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA sequencing (scRNA-seq) to identify epithelial cell types and associated biological processes involved in the pathogenesis of IPF. Transcriptomic analysis of normal human lung epithelial cells defined gene expression patterns associated with highly differentiated alveolar type 2 (AT2) cells, indicated by enrichm...
269 CitationsSource
#1Ivana V. Yang (Colorado School of Public Health)H-Index: 52
#2Christopher D. Coldren (University of Colorado Denver)H-Index: 25
Last. David A. Schwartz (University of Colorado Denver)H-Index: 126
view all 17 authors...
Background Idiopathic pulmonary fibrosis (IPF) is an untreatable lung disease with a median survival of only 3–5 years that is diagnosed using a combination of clinical, radiographic and pathologic criteria. Histologically, IPF is characterised by usual interstitial pneumonia (UIP), a fibrosing interstitial pneumonia with a pattern of heterogeneous, subpleural regions of fibrotic and remodelled lung. We hypothesised that gene expression profiles of lung tissue may identify molecular subtypes of ...
125 CitationsSource
#1Donavan T. Cheng (Hoffmann-La Roche)H-Index: 7
#2Deog Kyeom KimH-Index: 16
Last. Sreekumar G. PillaiH-Index: 31
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Rationale: Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.Objectives: To evaluate biomarkers associated with emphysema and COPD-related clinical characteristics, and to assess the relationships of soluble receptor for advanced glycation endproducts (sRAGE), a candidate systemic biomarker identified in this stud...
111 CitationsSource
#1Max A. SeiboldH-Index: 32
#2Anastasia L. Wise (University of Colorado Denver)H-Index: 2
Last. David A. Schwartz (University of Colorado Denver)H-Index: 126
view all 29 authors...
Background The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk. Methods Using a genomewide linkage scan, we detected linkage between idiopathic interstitial pneumonia and a 3.4-Mb region of chromosome 11p15 in 82 families. We then evaluated genetic variation in this region in gel-forming mucin genes expressed in the lung among 83 subjects with familial interstitial pneumonia, 492 subjects with idiopathic pulmonary fibrosis, and...
682 CitationsSource
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