American Journal of Respiratory Cell and Molecular Biology
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#1Médea PadraH-Index: 9
#2John Benktander (University of Gothenburg)H-Index: 10
Last. Magnus Paulsson (Lund University)H-Index: 8
view all 13 authors...
Chronic obstructive pulmonary disease (COPD) is associated with colonization by bacterial pathogens and repeated airway infections, leading to exacerbations and impaired lung function. The highly glycosylated mucins in the mucus lining the airways are an important part of the host defense against pathogens. However, mucus accumulation can contribute to COPD pathology. Here, we examined whether inflammation is associated with glycosylation changes that affect interactions between airway mucins an...
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#1Vitalii Kryvenko (University of Giessen)H-Index: 2
#2Miriam Wessendorf (University of Giessen)H-Index: 1
Last. István Vadász (University of Giessen)H-Index: 27
view all 7 authors...
Acute respiratory distress syndrome (ARDS) is often associated with elevated levels of CO2 (hypercapnia) and impaired alveolar fluid clearance. Misfolding of the Na,K-ATPase (NKA), a key molecule involved in both alveolar epithelial barrier tightness and in resolution of alveolar edema, in the endoplasmic reticulum (ER) may decrease plasma membrane (PM) abundance of the transporter. Here, we investigated how hypercapnia affects the NKA β-subunit (NKA-β) in the ER. Exposing murine precision-cut l...
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#1Megha Sharma (University of Arkansas for Medical Sciences)
#2Ujala Rana (MCW: Medical College of Wisconsin)H-Index: 7
Last. Girija G. Konduri (MCW: Medical College of Wisconsin)H-Index: 31
view all 9 authors...
Impaired angiogenesis function of pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN). Decreased nitric oxide (NO) levels in PPHN lead to impaired mitochondrial biogenesis and angiogenesis in the lung; the mechanisms remain unclear. We hypothesized that decreased cGMP-Protein kinase G (PKG) signaling downstream of NO leads to decreased mitochondrial biogenesis and angiogenesis in PPHN. PPHN was induced by ductus arteriosus constriction...
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#1Mindan Wu (ZJU: Zhejiang University)H-Index: 5
#2Tianwen Lai (ZJU: Zhejiang University)H-Index: 15
Last. Hai-Pin Chen (ZJU: Zhejiang University)H-Index: 8
view all 16 authors...
Airway epithelium is a central modulator of innate and adaptive immunity in the lung. Interleukin (IL)17A expression was found to be increased in airway epithelium; however, the role of epithelial-derived IL17A in chronic obstructive pulmonary disease (COPD) remains unclear. In this study, we aim to determine whether epithelial-derived IL17A regulates inflammation and mucus hyperproduction in COPD using a cultured human bronchial epithelial (HBE) cell line in vitro and airway epithelium IL17A-sp...
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#1Sabine Wronski (Fraunhofer Society)H-Index: 5
#2Soren Beinke (GSK: GlaxoSmithKline)H-Index: 6
Last. Gregor Warnecke (MHH: Hannover Medical School)H-Index: 29
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Human rhinovirus (RV) is a major risk factor for COPD and asthma exacerbations. Exploration of RV pathogenesis has been hampered by a lack of disease relevant model systems. We performed a detailed characterization of host responses to RV infection in human lung tissue ex vivo and investigated whether these responses are disease relevant for patients with COPD and asthma. In addition, impact of the viral replication inhibitor rupintrivir was evaluated. Human precision-cut lung slices (PCLS) were...
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#1Camilla Margaroli (UAB: University of Alabama at Birmingham)H-Index: 7
#2Derek Russell (UAB: University of Alabama at Birmingham)
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#1Björn Corleis (Ragon Institute of MGH, MIT and Harvard)H-Index: 9
#2Josalyn L Cho (Roy J. and Lucille A. Carver College of Medicine)H-Index: 1
Last. Tilo Winkler (Harvard University)H-Index: 27
view all 13 authors...
Smoking and HIV-1 infection are risk factors for COPD, which is among the most common comorbid conditions in people living with HIV-1. HIV-1 infection leads to persistent expansion of CD8+ T cells, and CD8+ T cell-mediated inflammation has been implicated in COPD pathogenesis. In this study, we investigated the effects of HIV-1 infection and smoking on T cell dynamics in patients at risk of COPD. Bronchoalveolar lavage (BAL), endobronchial brushings and blood from HIV-1 infected and uninfected n...
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#1Lu Gong (Brigham and Women's Hospital)H-Index: 5
#2Samuel Bates (Brigham and Women's Hospital)H-Index: 2
Last. Edwin K. Silverman (Brigham and Women's Hospital)H-Index: 127
view all 9 authors...
Chronic Obstructive Pulmonary Disease (COPD) is a common, complex disease and a major cause of morbidity and mortality. Although multiple genetic determinants of COPD have been implicated by genome-wide association studies (GWAS), the pathophysiologic significance of these associations remains largely unknown. From a COPD protein-protein interaction network module, we selected a network path between two COPD GWAS genes for validation studies: FAM13A-AP3D1-CTGF-TGFB2. We find that TGFβ2, FAM13A, ...
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