American Journal of Respiratory Cell and Molecular Biology
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6.91
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6,870
Papers 6,870
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#1Rod A. RahimiH-Index: 13
#2Josalyn L ChoH-Index: 2
Last. Anne I. SperlingH-Index: 41
view all 12 authors...
The mammalian airways and lungs are exposed to a myriad of inhaled particulate matter, allergens, and pathogens. The immune system plays an essential role in protecting the host from respiratory pathogens, but a dysregulated immune response during respiratory infection can impair pathogen clearance and lead to immunopathology. Furthermore, inappropriate immunity to inhaled antigens can lead to pulmonary diseases. A complex network of epithelial, neural, stromal, and immune cells has evolved to s...
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#1James T H Wong (UWA: University of Western Australia)
#2John G. Elliot (UWA: University of Western Australia)H-Index: 17
Last. Peter B. Noble (UWA: University of Western Australia)H-Index: 25
view all 7 authors...
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#1Jose F Perez-Zoghbi (CU: Columbia University)
#2Dannah Rae Sajorda (CU: Columbia University)
Last. Gene T Yocum (CUMC: Columbia University Medical Center)
view all 6 authors...
Asthma is a common respiratory disease characterized, in part, by excessive airway smooth muscle (ASM) contraction (airway hyperresponsiveness, AHR). Various γ-aminobutyric acid type A receptor (GABAAR) activators, including benzodiazepines, relax ASM. The GABAAR is a ligand-operated Cl- channel best known for its role in inhibitory neurotransmission in the central nervous system. Although ASM cells express GABAARs, affording a seemingly logical site of action, the mechanism(s) by which GABAAR l...
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#1Mojtaba Shekarkar Azgomi (University of Palermo)
#2Marco P La Manna (University of Palermo)
Last. Nadia Caccamo (University of Palermo)
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#1Kyung Sook Hong (CU: Cornell University)H-Index: 7
#2Kassandra Pagan (Cornell College)
Last. Soo Jung Cho (CU: Cornell University)
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Influenza infection induces lung epithelial cell injury via programed cell death. Glutathione, a potent antioxidant, has been reported to be associated with influenza infection. We hypothesized that lung epithelial cell death during influenza infection is regulated by glutathione metabolism. 8-week-old male and female BALB/c mice were infected with influenza (PR8: A/PR/8/34(H1N1)) via intranasal instillation. Metabolomic analysis were performed on whole lung lysate after influenza infection. For...
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#2Andrew V Rogers (Harefield Hospital)
Last. Pankaj K Bhavsar (Imperial College London)
view all 10 authors...
Mitochondrial dysfunction has been reported in chronic obstructive pulmonary disease (COPD). Transfer of mitochondria from mesenchymal stem cells to airway smooth muscle cells (ASMCs) can attenuate oxidative stress-induced mitochondrial damage. It is not known whether mitochondrial transfer occurs between structural cells in the lungs nor what role this may have in modulating bioenergetics and cellular function in healthy and COPD airways. Here, we show that ASMCs from both healthy ex-smoker and...
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#1Lk Metthew Lam (University of Pennsylvania)
#2Nilam S. Mangalmurti (University of Pennsylvania)H-Index: 17
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#1Atsushi Suzuki (Nagoya University)H-Index: 10
#2Koji Sakamoto (Nagoya University)H-Index: 22
Last. Jun Fukihara (Nagoya University)
view all 12 authors...
Fibroblasts play a central role in the lung fibrotic process. Our recent study identified a novel subpopulation of lung fibroblasts expressing meflin, anti-fibrotic properties of which were confirmed by murine lung fibrosis model. Meflin expressing fibroblasts were resistant to fibrogenesis induced by transforming growth factor-β (TGF-β), but its underlying mechanisms remain unknown. In this study, evaluation of a silica-nanoparticles-induced lung fibrosis model confirmed the antifibrotic effect...
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#1Umadevi Sajjan (Temple University)
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