Original paper
Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
Abstract
The multiplexed cancer cell line screening platform PRISM demonstrated its utility in testing hundreds of cell lines in a single run, possessing the potential to speed up anti-cancer drug discovery, validation and optimization. Here we described the development and implementation of a next-generation PRISM platform combining Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated gene editing, cell line DNA barcoding and...
Paper Details
Title
Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
Published Date
Jul 2, 2021
Journal
Volume
4
Issue
1
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Notes
History