Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy

This study sought to report the incidence of device-related thrombosis (DRT) and thromboembolic (TE) events when an alternative to clopidogrel is prescribed in loss-of-function (LOF) allele carriers of the cytochrome P450 2C19 (CYP2C19) gene.LOF polymorphisms of the CYP2C19 gene are associated with reduced hepatic bioactivation of clopidogrel.A total of 1,002 Watchman patients were included. Six hundred forty-five patients underwent CYP2C19...