3D printed calcium phosphate scaffolds with controlled release of osteogenic drugs for bone regeneration

The purpose of this research was to repair critical size defects of a skull. First, the CT data on the Beagle's skull were used to reconstruct an implant model. Then two Ф15 mm critical bone defects on the left and right sides of the skull were drilled. Hydroxyapatite, sodium alginate and icariin were adopted to formulate the printing inks according to their proportions. Calcium phosphate scaffolds with accuracy porosity were 3D printed by an...