Theoretical Investigation of some Antimalarial Sulfonamides as COVID-19 Drug Utilizing Computational Calculations and Molecular Docking Study

Reactivity investigation of N-(phenylsulfonyl)acetamide derivatives with nitrogen nucleophiles to give the corresponding aminothiazole, aminooxazole, 2H-benzo[b][1,4]oxazin-3-yl, 2H-benzo[b][1,4]thiazin-3-yl, quinoxalin-2-yl, pyridin-4-ylamino, benzo[d]thiazol-2-ylthio and 1H-benzo[d]imidazol-2-ylthio derivatives; respectively. The sulphonamides were examined in vitro antimalarial activity and characterized their ADMET properties, with IC50...