A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes

Importance

Observational studies suggest that statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, may be associated with beneficial effects in many noncardiovascular diseases.

Objective

To construct a weighted HMG-CoA reductase (HMGCR) gene genetic risk score (GRS) using variants in theHMGCRgene affecting low-density lipoprotein cholesterol as an instrumental variable for mendelian...