Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation

Volume: 206, Issue: 12, Pages: 3010 - 3020
Published: Jun 15, 2021
Abstract
Cyclic nucleotides cAMP and cGMP are important regulators of immune cell functions. Phosphodiesterases (PDEs) hydrolyze cAMP and/or cGMP and, thus, play crucial roles in cyclic nucleotide homeostasis. Abnormal alterations of PDE expression have been implicated in several diseases. To understand the function of PDEs in macrophages, we screened for all PDE genes in both peritoneal and alveolar macrophages from C57BL/6J mice and found that PDE4B...
Paper Details
Title
Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation
Published Date
Jun 15, 2021
Volume
206
Issue
12
Pages
3010 - 3020
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