The relationship between phthalate risk score and gestational age at delivery is mediated by cytochrome p450 derived eicosanoids: application of a novel analytical pipeline for high-dimensional multivariate mediation analysis

Background: There are diverse toxicological mechanisms that may mediate the impact of several toxicant classes (phthalates, phenols, polycyclic aromatic hydrocarbons, and metals) on pregnancy outcomes. However, there is a critical knowledge gap for the assessment of high-dimensional mediation with biomarkers of inflammation, oxidative stress, and lipid metabolism pathways (cytochrome p450, lipoxygenases, cyclooxygenases). The objective of this...