Preclinical Biodistribution and Human Radiation Dosimetry Estimates of [18F]FNP-59: a Radiotracer for Imaging Cholesterol Trafficking

1565 null Objectives: null null The synthesis and early preclinical evaluation of [18F]FNP-59, a novel fluorinated analogue of NP-59 and cholesterol, was previously reported.[1] In this work, studies were carried out to determine the biodistribution for human radiation dosimetry estimates of [18F]FNP-59 (Figure 1). NP-59 utility was limited due its high radiation dose; our objective is to demonstrate improved dosimetry and imaging properties...