Titanium(IV) oxide (TiO 2 , titania) is well-known for its excellent photocatalytic properties, wide bandgap, chemical resistance, and photostability. Nanostructured TiO 2 is extensively utilized in various electronic and energy-related applications such as resistive switching memory devices, flat panel displays, photodiodes, solar water-splitting, photocatalysis, and solar cells. This article presents recent advances in the design and nanostructuring of TiO 2 -containing antireflective self-cleaning coatings for solar cells. In particular, the energy harvesting efficiency of a solar cell is greatly diminished by the surface reflections and deposition of environmental contaminants over time. Nanostructured TiO 2 coatings not only minimize reflection through the graded transition of the refractive index but simultaneously improve the device’s ability to self-clean and photocatalytically degrade the pollutants. Thus, novel approaches to achieve higher solar cell efficiency and stability with pristine TiO 2 and TiO 2 -containing nanocomposite coatings are highlighted herein. The results are compared and discussed to emphasize the key research and development shortfalls and a commercialization perspective is considered to guide future research.