T-cell Exhaustion in Organ Transplantation.
Abstract
Exhaustion of T cells occurs in response to long-term exposure to self and foreign antigens. It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to clear chronic infections or eradicate tumors. T-cell exhaustion is associated with a specific transcriptional, epigenetic, and metabolic program and characteristic cell surface markers' expression. Recent studies have begun to elucidate the role of T-cell...
Paper Details
Title
T-cell Exhaustion in Organ Transplantation.
Published Date
Mar 1, 2022
Journal
Volume
106
Issue
3
Pages
489 - 499
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Notes
History