The Study on Potential Biomarker in Rat After Withdrawal of Cimaterol Using Untargeted Metabonomics

The present study was performed to screen the potential biomarkers of cimaterol in rat, using an untargeted metabonomics approach. The liver and serum samples were analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) after treatment of rats with cimaterol. The principal component analysis (PCA) and orthogonal projection to latent structures squares-discriminant analysis...