Rosiglitazone restores pulmonary surfactant and lipid homeostasis in mice exposed to ozone

Ozone is a ubiquitous urban air pollutant that causes airway inflammation and hyperresponsiveness. Evidence indicates that alterations in lung lipid homeostasis due to dysregulated catabolism by alveolar macrophages and/or disrupted recycling by alveolar epithelial type II cells drives inflammation and chronic lung injury. RNA-seq analysis of alveolar macrophages revealed that exposure of mice to ozone resulted in alterations in inflammatory and...