Development of Feed Forward and Conditional Models Based on Rodent Imaging Data to Predict Effects of Nitrogen Mustard on Pulmonary Function

Nitrogen mustard (NM; (bis(2-chloroethyl)methylamine) is a cytotoxic vesicant known to cause pulmonary damage. In these studies, we developed mathematical models that allow prediction of NM-induced functional deficits in the lung based on structural alterations identified by magnetic resonance imaging (MRI) and computed tomography (CT). Male Wistar rats were exposed to PBS (CTL) or NM (0.125 mg/kg) via i.t. instillation. CT and MRI scans were...