Original paper
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C
Abstract
Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of aberrant plasma cells within the bone marrow. The high frequent mutation of family with sequence similarity 46, member C (FAM46C) is closely related with the occurrence and progression of MM. Recently, FAM46C has been identified as a non-canonical poly(A) polymerase (PAP) that functions as a tumor suppressor in MM. This study aimed to elucidate the structural...
Paper Details
Title
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C
Published Date
May 28, 2021
Journal
Volume
41
Issue
7
Pages
615 - 630
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Notes
History