Development of a ZnO Nanowire Continuous Flow Microreactor with β-Glucosidase Activity: Characterization and Application for the Glycosylation of Natural Products

Published on Jun 7, 2021in ACS Sustainable Chemistry & Engineering7.632
· DOI :10.1021/ACSSUSCHEMENG.1C02557
Elena Gkantzou3
Estimated H-index: 3
(UoI: University of Ioannina),
Katerina Govatsi (FORTH: Foundation for Research & Technology – Hellas)+ 2 AuthorsHaralambos Stamatis35
Estimated H-index: 35
(UoI: University of Ioannina)
#1Hua Zhao (UNC: University of Northern Colorado)H-Index: 1
#1Hua Zhao (UNC: University of Northern Colorado)H-Index: 66
Last. Hua Zhao (UNC: University of Northern Colorado)
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Abstract Enzyme activity in nonaqueous media (e.g. conventional organic solvents) is typically lower than in water by several orders of magnitude. There is a rising interest of developing new nonaqueous solvent systems that are more “water-like” and more biocompatible. Therefore, we need to learn from the current state of nonaqueous biocatalysis to overcome its bottleneck and provide guidance for new solvent design. This review firstly focuses on the discussion of how organic solvent properties ...
3 CitationsSource
#1Sanaa Hafeez (LSBU: London South Bank University)H-Index: 5
#2E Aristodemou (LSBU: London South Bank University)H-Index: 10
Last. Achilleas Constantinou (LSBU: London South Bank University)H-Index: 13
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A Computational Fluid Dynamics (CFD) study has been conducted to assess the performance of packed bed and coated wall microreactors for the steam reforming of methanol with a CuO/ZnO/Al2O3 based catalyst (BASF F3-01). The results obtained were compared to experimental data from the literature to assess the validity and robustness of the models, and a good validation has been obtained. The performance of the packed bed and coated wall microreactors is similar at a constant reforming temperature. ...
5 CitationsSource
#1Pushplata Tripathi (IGNOU: Indira Gandhi National Open University)H-Index: 8
#2Sujata SinhaH-Index: 6
Industrial biocatalysts are gaining popularity each day for the purpose of eco-friendliness, cost-effectiveness and long-term sustainability. However, finding a suitable biocatalyst for any particular process fulfilling these criteria is still a challenging task and has to be taken care of for upscaling of the process. Emerging technologies are being adopted for the betterment of the process involving biocatalysis in terms of process economics and efficiency in terms of yield and productivity. V...
3 CitationsSource
#1Virginia VeneziaH-Index: 4
#2Aniello CostantiniH-Index: 19
Last. Valeria CalifanoH-Index: 9
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2 CitationsSource
#1Maria Romero-Fernandez (University of Nottingham)H-Index: 2
#2Francesca Paradisi (University of Bern)H-Index: 26
Abstract Enzymatic immobilization has been at the forefront of applied biocatalysis as it enables convenient isolation and reuse of the catalyst if the target reaction is conducted in batch, and it has opened up significant opportunities to conduct biocatalysis in continuous mode. Over the last few years, an array of techniques to immobilize enzymes have been developed, spanning from covalent multipoint attachment to noncovalent electrostatic strategies to rational architecture to suitably orien...
35 CitationsSource
#1Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
#2Angeliki C. Polydera (UoI: University of Ioannina)H-Index: 8
Last. Haralambos Stamatis (UoI: University of Ioannina)H-Index: 35
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Abstract The preparation, characterization and application of a novel robust nanobiocatalyst, developed through the covalent binding of lipase B from Pseudozyma antarctica on magnetic hierarchically porous carbon materials (HPCFe), is reported. The nanobiocatalyst was characterized by combination of spectroscopic and microscopic techniques. Structural and catalytic characterization indicates that HPCFe nanostructures create a microenvironment which stabilizes the structure of the immobilized enz...
5 CitationsSource
#1John M. Woodley (DTU: Technical University of Denmark)H-Index: 66
Abstract Today enzymatic catalysis is widely used in the pharmaceutical industry and is expanding fast into the fine and specialty chemicals sector, driven by the need for evermore sustainable chemistry. This review highlights the increasing emphasis now placed on achieving better process performance metrics to reflect the demand for cost-effective and scalable processes, ready for direct implementation into industry. The review also highlights other developments at the frontiers of this field i...
32 CitationsSource
#1Xiaojuan Li (Northeast Normal University)H-Index: 1
#2Zhengri Yin (Yanbian University)H-Index: 1
Last. Li Yang (Northeast Normal University)H-Index: 23
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We report the first application of hydrophobic interaction between graphene oxide (GO) and negatively charged enzymes to fabricate CE‐integrated immobilized enzyme microreactors (IMERs) by a simple and reliable immobilization procedure based on layer by layer assembly. L‐lactate dehydrogenase (L‐LDH), which is negatively charged during the enzymatic reaction, is selected as the model enzyme. Various spectroscopic techniques, including SEM, FTIR, and UV‐vis are used to characterize the fabricated...
7 CitationsSource
#1Zhi-Feng Zhong (Fujian Medical University)H-Index: 3
#2Jing HanH-Index: 5
Last. Lidian Chen (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 30
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Salidroside, a phenylpropanoid glycoside, is a main bioactive component of Rhodiola rosea L. Previous studies have indicated that salidroside has prominent anti-stroke effects in cerebral ischemia/reperfusion models. But the underline mechanisms involved are not well understood. This study was designed to illustrate the anti-stroke effects of salidroside on MCAO-induced models in rats and its potential mechanisms on dopaminergic system. We discovered that administration with salidroside increase...
7 CitationsSource
Abstract The use of immobilized enzymes is now a routine process for the manufacture of many industrial products in the pharmaceutical, chemical and food industry. Some enzymes, such as lipases, are naturally robust and efficient, can be used for the production of many different molecules and have a wide range of industrial applications thanks to their broad selectivity. As an example, lipase from Candida antarctica (CalB) has been used by BASF to produce chiral compounds, such as the herbicide ...
142 CitationsSource
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