Bioanalysis of selinexor in mouse plasma micro-samples utilizing UPLC-MS/MS

Selinexor, a first-in-class inhibitor of the nuclear export protein Exportin-1 (XPO1), was recently approved for the treatment of multiple myeloma in combination with dexamethasone, and as monotherapy for diffuse large B-cell lymphoma. To enable investigations of selinexor in mice, we established and validated an ultrahigh-performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS) assay in the plasma concentration range of 1–1000...