Role of pharmacogenomics in T-cell hypersensitivity drug reactions
Volume: 21, Issue: 4, Pages: 327 - 334
Published: May 25, 2021
Abstract
An update of the pharmacogenetic risk factors associated with T-cell-mediated delayed hypersensitivity reactions.Recent HLA associations relevant to our understanding of immunopathogenesis and clinical practice include HLA-B∗13:01 with co-trimoxazole-induced SCAR, and HLA-A∗32:01 with vancomycin-DRESS, for which an extended HLA class II haplotype is implicated in glycopeptide antibiotic cross-reactivity. Hypoactive variants of ERAP1, an...
Paper Details
Title
Role of pharmacogenomics in T-cell hypersensitivity drug reactions
Published Date
May 25, 2021
Volume
21
Issue
4
Pages
327 - 334
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