Gradient regulation of osteo-immune microenvironment by chitooligosaccharide-containing ion-doped mesoporous silica nanoparticles to accelerate osteogenesis

Tissue repair can be induced subsequently by the early inflammatory response after biomaterial implantation. However, the accomplishment of late regeneration process requires inhibit inflammation. This study aims to realize the gradient regulation of osteogenic immune micro-environment regenerating lost bone tissues by utilizing the synergistic effect of chitooligosaccharides (COS) and inorganic ions. Zinc (Zn)-Calcium (Ca)-Strontium (Sr) doped...