Industry updates from the field of stem cell research and regenerative medicine in April 2021.

Dusko Ilic; Mirjana Liovic

doi:10.2217/RME-2021-0065

Published on Jun 2, 2021in Regenerative Medicine2.598

· DOI :10.2217/RME-2021-0065

Dusko Ilic49

Estimated H-index: 49

('KCL': King's College London), Mirjana Liovic13

Estimated H-index: 13

(University of Ljubljana)

Abstract

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in April 2021.

References1

Newest

Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells.

Jan 1, 2005·Nature Biotechnology36.56

#1Marie-Catherine Giarratana (University of Paris)H-Index: 2

#2Ladan Kobari (University of Paris)H-Index: 3

Last. Luc Douay (University of Paris)H-Index: 37

view all 9 authors...

We describe here the large-scale ex vivo production of mature human red blood cells (RBCs) from hematopoietic stem cells of diverse origins. By mimicking the marrow microenvironment through the application of cytokines and coculture on stromal cells, we coupled substantial amplification of CD34+ stem cells (up to 1.95 × 106-fold) with 100% terminal differentiation into fully mature, functional RBCs. These cells survived in nonobese diabetic/severe combined immunodeficient mice, as do native RBCs...more

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