Leptospirosis in febrile patients with suspected diagnosis of dengue fever.

Published on May 29, 2021in BMC Research Notes
· DOI :10.1186/S13104-021-05627-3
Juana del Valle-Mendoza10
Estimated H-index: 10
(UPC: Universidad Peruana de Ciencias Aplicadas),
Carlos Palomares-Reyes5
Estimated H-index: 5
(UPC: Universidad Peruana de Ciencias Aplicadas)
+ 9 AuthorsWilmer Silva-Caso9
Estimated H-index: 9
(UPC: Universidad Peruana de Ciencias Aplicadas)
Source
Abstract
OBJECTIVE This study was carried out to determine the prevalence of leptospirosis among febrile patients with a suspicious clinical diagnosis of dengue fever in northern Peru. RESULTS A total of 276 serum samples from patients with acute febrile illness (AFI) and suspected diagnosis for dengue virus (DENV) were analyzed. We identified an etiological agent in 121 (47.5%) patients, DENV was detected in 30.4% of the cases, leptospirosis in 11.2% and co-infection by both pathogens was observed in 5.9% of the patients. In this study the most common clinical symptoms reported by the patients were: headache 89.1%, myalgias 86.9% and arthralgias 82.9%. No differences in symptomatology was observed among the different study groups.
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#1Johanna Martins-Luna (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 4
#2Juana del Valle-Mendoza (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 10
Last. Miguel Angel Aguilar-Luis (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 9
view all 9 authors...
Objective To evaluate the frequency of infection caused by the Oropouche virus (OROV) in 496 patients with acute febrile disease (AFI), whose samples were obtained for the analysis of endemic arboviruses in a previous investigation carried out in 2016.
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Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected, reemerging disease of global public health importance with respect to morbidity and mortality both in humans and animals. Due to negligence, rapid, unplanned urbanization, and poor sanitation, leptospirosis emerges as a leading cause of acute febrile illness in many of the developing countries. Every individual has a risk of getting infected as domestic and wild animals carry leptospires; the at-risk population vari...
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#1Ashley L. St. John (NUS: National University of Singapore)H-Index: 28
#2Abhay P. S. Rathore (Duke University)H-Index: 19
Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination coverage, pre-existing immunity to dengue virus is abundant in the human population, and secondary dengue infections are common. Here, we contrast the mechanisms initiating and sustaining adaptive immune responses during primary infection with the immune pathways that are pre-existing and reactivated during secondary ...
49 CitationsSource
#1Fiorella Ricapa-Antay (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 1
#2Katia Diaz-Melon (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 1
Last. Juana del Valle-Mendoza (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 10
view all 11 authors...
Acute febrile illness (AFI) represent a significant health challenge in the Peruvian Amazon basin population due to their diverse etiologies and the unavailability of specific on-site diagnostic methods, resulting in underreporting of cases. In Peru, one of the most endemic regions to dengue and leptospirosis is Madre de Dios, a region also endemic to emergent bacterial etiologic agents of AFI, such as bartonellosis and rickettsiosis, whose prevalence is usually underreported. We aimed to molecu...
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#1Arun Sachu (T. D. Medical College)H-Index: 1
#1Arun SachuH-Index: 3
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Background and Objectives: Dengue and Leptospirosis were often discussed separately with rash being more common in dengue and jaundice in leptospirosis. But with increasing reports of co-infection, the situation has become worse. The main objective of this study was to look for the presence of both Dengue and Leptospira IgM antibodies in serum samples of patients, presenting with acute febrile illness. Medical records of the co-infected patients were examined to analyse the clinical features and...
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#1José Cláudio Fonseca Moreira (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 25
#2Clarisse da Silveira Bressan (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
Last. André Siqueira (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 11
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Abstract Background The causes of acute febrile illness (AFI) in Latin America are diverse and their complexity increases as the proportion of fever due to malaria decreases, as malaria control measures and new pathogens emerge in the region. In this context, it is important to shed light on the gaps in the epidemiological characteristics and the geographic range for many AFI aetiologies. Objectives To review studies on community-acquired fever aetiology other than malaria in Latin America, and ...
24 CitationsSource
#1Vanina Guernier (WHO: World Health Organization)H-Index: 17
#2Cyrille Goarant (Pasteur Institute)H-Index: 28
Last. Colleen L. Lau (ANU: Australian National University)H-Index: 21
view all 4 authors...
Background The Pacific Islands have environmental conditions highly favourable for transmission of leptospirosis, a neglected zoonosis with highest incidence in the tropics, and Oceania in particular. Recent reports confirm the emergence and outbreaks of leptospirosis in the Pacific Islands, but the epidemiology and drivers of transmission of human and animal leptospirosis are poorly documented, especially in the more isolated and less developed islands. Methodology/Principal findings We conduct...
33 CitationsSource
#1Thales de Brito (USP: University of São Paulo)H-Index: 21
#2Ana Maria Gonçalves da Silva (USP: University of São Paulo)H-Index: 16
Last. Patrícia A.E. Abreu (Instituto Butantan)H-Index: 16
view all 3 authors...
Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil contaminated with urine from infected animals. Leptospires enter the body by penetrating mucous membranes or skin abrasions and disseminate through the hematogenic route. In humans, leptospirosis may cause a wide spect...
17 CitationsSource
#1Carlos Alva-Urcia (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 1
#2Miguel Angel Aguilar-Luis (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 9
Last. Juana del Valle-Mendoza (UPC: Universidad Peruana de Ciencias Aplicadas)H-Index: 10
view all 10 authors...
Background Arboviral diseases are one of the most common causes of acute febrile illness (AFI) and a significant health problem in South America. In Peru, laboratory etiologic identification of these infections occurs in less than 50% of cases, leading to underdiagnoses of important emerging arboviruses. Aim To assess the prevalence of the Dengue (DENV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and Zika (ZIKV) viruses in patients with acute febrile illness from Puerto Maldonado (Peru...
22 CitationsSource
#1Jeyanthi Suppiah (UPM: Universiti Putra Malaysia)H-Index: 5
#2Shie-Yien Chan (UPM: Universiti Putra Malaysia)H-Index: 1
Last. Hui-Yee Chee (UPM: Universiti Putra Malaysia)H-Index: 10
view all 8 authors...
Background Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection.
7 CitationsSource
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