Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis

Owing to the low solubility of 5-aminosalicylic acid (5-ASA), a first-line drug for treatment of ulcerative colitis (UC), oral and local administration are challenging, leading to a low utilization rate. Here, we applied generation 4 polyamidoamine (G4 PAMAM) dendrimer to construct a G4-ASA nanoparticle, via a host–guest interaction, containing surface amino groups to crosslink the aldehyde group of the oxidized dextran by a Schiff base...