pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

A pH-responsive drug delivery system composed of N-(propyl)aniline (N-ANI) modified mesoporous silica nanoparticles as a carrier, and β-cyclodextrin (β-CD) as a cap was prepared and investigated. The system was studied for co-adsorption and co-delivery of two different drugs; an anticancer drug 5-fluorouracil (5-FU), and anti-inflammatory agent naproxen (NAP). Detailed adsorption study of the drugs themselves as well as in their mutual mixture...