FORMULATION DEVELOPMENT AND CHARACTERIZATION OF NADIFLOXACIN LOADED SOLID LIPID NANOPARTICLE BASED HYDROGEL

The aim of this dissertation work was to develop and characterize an optimal formulation of solid lipid nanoparticles of nadifloxacin, which would then be incorporated into hydrogel. The SLN was developed with drug nadifloxacin, which is poorly water soluble. On the basis of solubility studies (i.e. partitioning effects), the lipid and components were chosen. In this study, the two variables amount of lipid and concentration of Poloxamer 188...