One-step preparation of the engineered titanium implant by rationally designed linear fusion peptides with spacer-dependent antimicrobial, anti-inflammatory and osteogenic activities

Biomaterial-associated infection (BAI) and delayed osseointegration are two major limitations for orthopeadic titanium implants, which are highly required in clinic implants. Herein, we rationally design a series of novel fusion peptides (FPs) based on HHC36 and BFP1 with different polyethylene glycol (PEG) spacers, and covalently immobilize them onto titanium implants via a one-step reaction between thiol groups and titanium hydroxyl groups....