Simulating the dynamics of atherosclerosis to the incidence of myocardial infarction, applied to the KORA population

Analyzing epidemiological data with simplified mathematical models of disease development provides a link between the time‐course of incidence and the underlying biological processes. Here we point out that considerable modeling flexibility is gained if the model is solved by simulation only. To this aim, a model of atherosclerosis is proposed: a Markov Chain with continuous state space which represents the coronary artery intimal surface area...