Evidence of cellular proliferation in the spinal cord and hippocampus in an animal model of osteoarthritis

Osteoarthritis is a degenerative joint disease that involves articular cartilage destruction, local inflammatory response, pain and hypersensitivity to mechanical and thermal stimulation. Sensitization in the joint has been shown to change the dynamics of central neural networks leading to nociceptive behaviors, learning and adaptation. In this study, we hypothesize that perturbation of local equilibrium, caused by flooding of excitatory...