Synthesis, characterization, and biomedical assessment of novel bisimidazole–coumarin conjugates

In an attempt to find versatile and readily accessible coumarin scaffolds with a broad spectrum of biomedical properties, seven bisimidazole–coumarin conjugates were synthesized through several steps starting from metacetamol and malonic acid. Spectroscopical techniques including FTIR, 1H-NMR, and 13C-NMR were employed to confirm the chemical backbone of the synthesized conjugates. Their biomedical potentials to behave as anti-tumorous,...