Internal medicine

Glycolysis

Alcoholic liver disease

Disease

Pathogenesis

Biology

PKM2

Endocrinology

Hepatic stellate cell

Immunology

Cirrhosis

Pyruvate kinase

Fatty liver

Metabolism

Cell biology

Cancer research

Medicine

Cell Metabolism

Non-alcoholic fatty liver disease (NAFLD) is associated with increased inflammation. Moreno-Fernandez et al. now show that the steatotic liver microenvironment gives rise to a distinct inflammatory hepatic Th17 (ihTh17) cell subset, which preferentially utilizes the glycolytic pathway to fuel tissue inflammation and promote NAFLD progression.

PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease