Original paper
Pyruvate carboxylase and cancer progression
Abstract
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant tissue, PC plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells. In breast cancer, PC activity is...
Paper Details
Title
Pyruvate carboxylase and cancer progression
Published Date
Apr 30, 2021
Journal
Volume
9
Issue
1