Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

Background Ferroptosis is essential to regulate tumor growth and serves as a promising therapeutic target to lung cancer. Ubiquitin‐specific protease 35 (USP35) belongs to the deubiquitinases family that is associated with cell proliferation and mitosis. In this research, we aim to elucidate the potential role and molecular basis of USP35 in lung cancer. Methods Lung cancer cells were infected with lentiviral vectors to silence or overexpress...