Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations

Volume: 49, Issue: 13, Pages: e75 - e75
Published: Apr 27, 2021
Abstract
Technological advances in rare DNA mutations detection have revolutionized the diagnosis and monitoring of tumors, but they are still limited by the lack of supersensitive and high-coverage procedures for identifying low-abundance mutations. Here, we describe a single-tube, multiplex PCR-based system, A-Star, that involves a hyperthermophilic Argonaute from Pyrococcus furiosus (PfAgo) for highly efficient detection of rare mutations beneficial...
Paper Details
Title
Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations
Published Date
Apr 27, 2021
Volume
49
Issue
13
Pages
e75 - e75
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