A Reflection on the Mechanism of the Role of Nanoparticles in Increasing the Efficacy of Anti-tumour Properties of Docetaxel

Docetaxel is an important cancer therapeutic drug that targets microtubules. As a taxane, it has high cytotoxic potential and causes cell death by inducing polymerization of tubulin monomers and inhibiting depolymerization or inducing apoptosis by stimulating the phosphorylation B-cell lymphoma 2 (Bcl-2). As a hydrophobic drug, the clinical application of docetaxel is limited. The nanoparticle-based platforms as drug carriers have opened up the...