Loliolide, isolated from Sargassum horneri; abate LPS-induced inflammation via TLR mediated NF-κB, MAPK pathways in macrophages

The secondary metabolite terpene lactone; 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one; (Loliolide) from Sargassum horneri which is abundant on the shores of South Korea was investigated for its anti-inflammatory properties in RAW 264.7 macrophages under LPS stimulation. Isolation and identification were assisted by HPCPC, HPLC-MS, GC–MS, and NMR. Initial assessments of NO production downregulation influenced further...