Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use

Published on Apr 12, 2021
· DOI :10.20538/1682-0363-2021-1-23-30
O. D. Bragina3
Estimated H-index: 3
(RAS: Russian Academy of Sciences),
V. I. Chernov2
Estimated H-index: 2
(RAS: Russian Academy of Sciences)
+ 4 AuthorsV. M. Tolmachev1
Estimated H-index: 1
(Tomsk Polytechnic University)
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ContextERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA.ObjectivesTo establish an evidence-based guideline for HER2 testing in patients with GEA, formalize the algorithms for methods to improve the accuracy of HER2 testing while addressing which patients and...
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Background. null null null The chief goal in assessing the Her2/neu status in clinical practice is to identify indications for targeted therapy. The main methods for determining the Her2/neu status are an immunohistochemical method and fluorescence in situ hybridization (FISH); however, despite their widespread use, they have a number of significant disadvantages. Over the past few years, radionuclide diagnosis using a new class of alternative scaffold proteins that meet all the requirements for...
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