Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use

Published on Apr 12, 2021
· DOI :10.20538/1682-0363-2021-1-23-30
O. D. Bragina3
Estimated H-index: 3
(RAS: Russian Academy of Sciences),
V. I. Chernov2
Estimated H-index: 2
(RAS: Russian Academy of Sciences)
+ 4 AuthorsV. M. Tolmachev1
Estimated H-index: 1
(Tomsk Polytechnic University)
Source
Abstract
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References20
Newest
#6Anna Orlova (Tomsk Polytechnic University)H-Index: 56
#7A. V. Medvedeva (RAS: Russian Academy of Sciences)H-Index: 5
Radionuclide molecular imaging of human epidermal growth factor (HER2) expression may be helpful to stratify breast and gastroesophageal cancer patients for HER2-targeting therapies. ADAPTs (albumin-binding domain derived affinity proteins) are a new type of small (46-59 amino acids) proteins useful as probes for molecular imaging. The aim of this first-in-human study was to evaluate biodistribution, dosimetry, and safety of the HER2-specific 99mTc-ADAPT6. METHODS: Twenty-nine patients with prim...
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Last. М. С. ЛарькинаH-Index: 1
view all 6 authors...
This review discusses a relatively new class of targeted molecules that is being actively studied for radionuclide diagnosis and treatment of malignancies. The full-size antibodies used so far have non-optimal pharmacological properties, slow distribution in the body, poor penetration into the tissue and kidney excretion, and high immunogenicity, which significantly complicates their use in clinical practice. Over the past decade, a new class of targeted molecules, called “non-immunoglobulin sca...
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#1Anzhelika Vorobyeva (Uppsala University)H-Index: 11
#2Alexey A. Schulga (RAS: Russian Academy of Sciences)H-Index: 16
Last. Sergey M. Deyev (Tomsk Polytechnic University)H-Index: 29
view all 12 authors...
Radionuclide molecular imaging of HER2 expression in disseminated cancer enables stratification of patients for HER2-targeted therapies. DARPin G3, a small (14 kDa) engineered scaffold protein, is a promising probe for imaging of HER2. We hypothesized that position (C- or N-terminus) and composition (hexahistidine or (HE)3) of histidine-containing tags would influence the biodistribution of [99mTc]Tc(CO)3-labeled DARPin G3. To test the hypothesis, G3 variants containing tags at N-terminus (H6-G3...
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#1Ahmet KrasniqiH-Index: 8
Last. Vladimir Tolmachev (Uppsala University)H-Index: 62
view all 8 authors...
Imaging of expression of therapeutic targets may enable patients' stratification for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chai ...
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view all 6 authors...
The main trends and prospects of development of nuclear medicine, problems and possible ways of their solution are considered in the article. The main scientific directions in the development of radiopharmaceuticals for the diagnosis and radionuclide therapy of malignant tumors (radiopharmaceuticals that can accumulate in tissues surrounding the tumor; radiopharmaceuticals that can accumulate on the membranes of tumor cells, radiopharmaceuticals that can accumulate in tumor cells, radiopharmaceu...
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#1Rudo Simeon (A&M: Texas A&M University)H-Index: 7
#2Zhilei Chen (A&M: Texas A&M University)H-Index: 17
Antibodies have proved to be a valuable mode of therapy for numerous diseases, mainly owing to their high target binding affinity and specificity. Unfortunately, antibodies are also limited in several respects, chief amongst those being the extremely high cost of manufacture. Therefore, non-antibody binding proteins have long been sought after as alternative therapies. New binding protein scaffolds are constantly being designed or discovered with some already approved for human use by the FDA. T...
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#1Asim Azhar (AMU: Aligarh Muslim University)H-Index: 6
#2Ejaj Ahmad (AMU: Aligarh Muslim University)H-Index: 13
Last. Ghulam Md Ashraf (KAU: King Abdulaziz University)H-Index: 36
view all 6 authors...
Abstract Antibodies occupy a central position when it comes to binding proteins with desired antigenic specificities. During the past decade, a plethora of recombinant or humanized versions of antibodies have entered clinical settings with outstanding accomplishments. Yet, they suffer from several drawbacks such as high molecular weight, limited tissue penetration, instability, high production cost, requirement for large doses and potential cytotoxicity. As a result, new generation of receptor p...
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#1Angela N. Bartley (Vandy: Vanderbilt University)H-Index: 8
#2Mary Kay Washington (Vandy: Vanderbilt University)H-Index: 66
Last. Jaffer A. Ajani (Vandy: Vanderbilt University)H-Index: 125
view all 15 authors...
ContextERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA.ObjectivesTo establish an evidence-based guideline for HER2 testing in patients with GEA, formalize the algorithms for methods to improve the accuracy of HER2 testing while addressing which patients and...
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Currently, there is a urgent need to search for new diagnostic methods that allow us to reveal malignant tumors with the overexpression of Her-2/neu with high accuracy. In recent years radioisotope methods have been actively developing to identify specific tumor targets, with antibodies being the “targeting” module. The purpose of the study. Creation of a chemically stable radiochemical compound for the imaging of cells with the overexpression of Her-2/neu. Materials and methods. The study was c...
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#1R. ZeltchanH-Index: 3
#2A. A. MedvedevaH-Index: 5
Last. V. S. SkuridinH-Index: 6
view all 9 authors...
Purpose: to study the potential utility of 1-thio-D-glucose labeled with 99mTc for cancer imaging in laboratory animals. Materials and method: the study was carried out in cell cultures of normal CHO (Chinese hamster ovary cells CHO) and malignant tissues MCF-7 (human breast adenocarcinoma MCF-7). To evaluate the uptake of 99mTc-1-thio-D-glucose in normal and tumor tissue cells, 25 MBq of 1-thio-D-glucose labeled with 99mTc was added to the vials with 3 million cells and incubated for 30 min at ...
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Cited By1
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#1O. D. Bragina (RAS: Russian Academy of Sciences)H-Index: 3
#2V. I. Chernov (RAS: Russian Academy of Sciences)H-Index: 2
Last. V. M. Tolmachev (Tomsk Polytechnic University)H-Index: 1
view all 8 authors...
Source
Background. null null null The chief goal in assessing the Her2/neu status in clinical practice is to identify indications for targeted therapy. The main methods for determining the Her2/neu status are an immunohistochemical method and fluorescence in situ hybridization (FISH); however, despite their widespread use, they have a number of significant disadvantages. Over the past few years, radionuclide diagnosis using a new class of alternative scaffold proteins that meet all the requirements for...
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