Hemodynamics

2019-20 coronavirus outbreak

Dobutamine

Nuclear physics

Virology

TRACER

Psychiatry

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Outbreak

Coronavirus disease 2019 (COVID-19)

Physics

Psychology

Infectious disease (medical specialty)

Internal medicine

Mental health

Medicine

Chemistry

Nuclear medicine

Disease

Evidence-Based Mental Health

In this study, we compared the accuracy of the rate of myocardial glucose use (rMGU) measured using PET and 1-11C-glucose with the rate measured using PET and the more conventional tracer 18F-FDG. Methods: PET measurements of myocardial tracer uptake (K, in mL/g/min) and rMGU (in nmol/g/min) were obtained with 1-11C-glucose and 18F-FDG in 21 dogs using kinetic modeling and the Patlak graphical method, respectively. Eighteen dogs were studied during hyperinsulinemic-euglycemic clamp performed either at rest or combined with phenylephrine, dobutamine, intralipid infusion, or intralipid infusion and dobutamine. Three dogs were studied during intralipid infusion alone under resting conditions. Arterial-coronary sinus sampling was performed to measure the K of both tracers (n = 14) and rMGU by the Fick method (n = 21). Results: PET-derived values for K from either 1-11C-glucose or 18F-FDG correlated closely with directly measured tracer K values (glucose: y = 0.98x + 0.01, r = 0.79, P &lt; 0.001; 18F-FDG: y = 0.74x + 0.03, r = 0.77, P &lt; 0.001). In contrast, correlation with K values of unlabeled glucose measured directly was better for 1-11C-glucose (y = 0.92x + 0.02, r = 0.96, P &lt; 0.0001) than for 18F-FDG (y = 0.66x + 0.05, r = 0.72, P &lt; 0.01) (P &lt; 0.001 for comparison of correlation coefficients). As a consequence, PET-derived values for rMGU correlated more closely with Fick-derived measurements of unlabeled glucose using 1-11C-glucose (y = 0.82x + 168, r = 0.97, P &lt; 0.0001) than with 18F-FDG (y = 0.81x + 278, r = 0.79, P &lt; 0.001) (P &lt; 0.001 for comparison of correlation coefficients). Conclusion: Over a wide range of conditions, PET-derived measurements of rMGU are obtained more accurately with 1-11C-glucose than with 18F-FDG.

COVID-19 vaccines, hesitancy and mental health