Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Abstract
Skin scarring, the end result of adult wound healing, is detrimental to tissue form and function. Engrailed-1 lineage-positive fibroblasts (EPFs) are known to function in scarring, but Engrailed-1 lineage-negative fibroblasts (ENFs) remain poorly characterized. Using cell transplantation and transgenic mouse models, we identified a dermal ENF subpopulation that gives rise to postnatally derived EPFs by activating Engrailed-1 expression during...
Paper Details
Title
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Published Date
Apr 23, 2021
Journal
Volume
372
Issue
6540
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